Biomedicine and Biotechnology
Annotation: This subject focuses on educating students in biomedical research and biotechnologies. It teaches the basis of scientific work, introduction to methodology in biomedicine up to the development of novel diagnostics and therapeutics. Lectures and seminars will contain the insight into modern tools such as transgenic biology or global technologies such as OMICs.
Summer Term (ACADEMIC YEAR 2023/2024)
Lectures will be held in BIOCEV (Seminary Room U2.020 or U1.037, Průmyslová 595, 252 50 Vestec) starting from February 22nd, 2024, from 4 PM. Students are encouraged to read education material listed below ahead of the seminar. In case of questions, please do not hesitate to contact Lucie Vyšatová (lucie.vysatova@lf1.cuni.cz, +420 325 873 031)
RNDr. Jiří Zahradník, PhD
Title: Protein engineering in biomedicine
State-of-the-art protein engineering is progressively asserting itself in biomedicine in a plethora of tasks such as adjustment, amplification, or attenuation of immune responses, development of new diagnostic and therapeutic modalities, and strategies to treat multiple infectious, autoimmune, and neoplastic diseases.
Study material: [SM1]
prof. MUDr. Karel Smetana, DrSc.
Title: Tumor ecosystem
Tumors are composed of cancer cells as well as non-malignant cells such as infiltrating leukocytes and cancer-associated fibroblasts. These non-malignant cells participate in the control of cancer cell differentiation, proliferation and migration via extensive intercellular dialogue utilizing the paracrine secretion of many bioactive factors. The principle of their activity will be shown as an example of cancer-associated fibroblasts.
Study material: [PDF1][PDF2][PDF3][PDF4]
Assoc. Prof. RNDr. Jiří Petrák, Ph.D.
Title: CLINICAL PROTEOMICS
Using efficient separation methods and high-resolution mass spectrometry PROTEOMICS enables monitoring of quantitative and qualitative changes of thousands of proteins in biological samples. Detailed knowledge of proteome changes in cells and tissues can elucidate molecular mechanisms of physiologic and pathologic processes, and identify disease markers or novel therapeutic targets.
Study material: [PDF1][PDF2]
Prof. MUDr. Tomáš Stopka, Ph.D.
Title: CELL BIOLOGY: Epigenetic control of stem cell decisions
Regulatory mechanisms in normal cell differentiation including transcription factors and their effector pathways. Biology of stem cells and tissue transplantation. Regulation of cell cycle and its detection.
Study material: [PDF1][PDF2][PDF3][PDF4][PDF5]
RNDr. Radoslav Janoštiak, Ph.D.
Title: Biology of solid tumors and translational medicine
Basic principles of cancer development, cancer driver mutations and targeted therapy, cancer evolution and progression, cancer cell dormancy and invasiveness, circulating tumor cells.
Study material: [PDF1] [PDF2] [PDF3] [PDF4]
Assoc. Prof. Ondřej Havránek, MD, PhD
Title: GENETICS
Cancer genomes and genome editing technology
Cancer associated acquired DNA mutations and their role in tumor development, progression, and therapy resistance. Consequences for interaction of tumor cells with immune system. Use of genome modifying technologies to create models for cancer research and options for therapy.
Study material: [PDF1][PDF2][PDF3][PDF4][PDF5][PDF6][PDF7][PDF8][PDF9][PDF10]
Mgr. Miroslav Hons, PhD
Title: LEUKOCYTE MIGRATION AND IMMUNOLOGY
Migration of leukocytes in healthy and pathological states. Imaging of leukocyte behaviour and interactions. Cell biology of leukocyte motility.
RNDr. Kristýna Pimková, Ph.D.
Title: Redox Biology
Reactive oxygen and nitrogen species are not just harmful by-products that cause damage to macromolecules and ultimately cell death. They are essential signaling molecules that play a role in basic biological processes, so-called "redox signaling". The basic principles of redox signalling, its role in physiological cellular processes and in cancer will be discussed.
Study material: [SM1][SM2][SM3][SM4][SM5]
