As part of new grant projects, the Laboratory of Lymphoma Tumor Biology, based in the modern BIOCEV scientific center, is seeking talented and motivated candidates for PhD studies. The laboratory offers a unique opportunity to engage in cutting-edge lymphoma research within an environment that brings together leading scientists from the Czech Academy of Sciences and Charles University.

New members will learn a wide range of modern laboratory and bioinformatic techniques, have the opportunity to apply for their own grants, and publish results in prestigious international journals. Research topics cover both basic and preclinical studies, providing a comprehensive perspective on lymphoma biology.

Offered topics:

Molecular mechanisms of B-cell receptor signaling in EZB diffuse large B-cell lymphoma

- The main focus of the project is to determine how somatic genetic alterations affect B-cell receptor signaling in the most common type of lymphoma. Based on literature and our preliminary data, it is assumed that these alterations influence the dynamics of cortical actin and related B-cell receptor signaling.

Treatment of lymphomas using organoid models without the use of chemotherapeutics

- The proposed project aims to develop innovative chemo-free therapeutic strategies through organoid in vitro models that faithfully mimic the complex interactions between tumor cells and their microenvironment. These interactions cannot be explored in detail in conventional 2D cell models, which significantly limits the current understanding of the molecular mechanisms of lymphomagenesis and therapeutic resistance.

We offer work in a friendly environment within a dynamic group with established international cooperation, operating in a modern scientific center with first-class research facilities. As part of your studies, you will have the opportunity to complete a 6-12 month internship abroad.

Fully funded positions are available with an expected start date in the 2026/2027 academic year.

If you are interested, please send your CV and a short summary of why you would be interested in working in our group to the following email address: ondrej.havranek@lf1.cuni.cz.