As part of new grant projects, the Laboratory of Lymphoma Tumor Biology, based in the modern BIOCEV scientific center, is seeking talented and motivated candidates for PhD studies. The laboratory offers a unique opportunity to engage in cutting-edge lymphoma research within an environment that brings together leading scientists from the Czech Academy of Sciences and Charles University.
PhD students will learn a wide range of modern laboratory and bioinformatic techniques, have the opportunity to apply for their own grants, and publish results in prestigious international journals. Research topics cover both basic and preclinical studies, providing a comprehensive perspective on lymphoma biology.
Offered topics:
- The main focus of the project is to determine how somatic genetic alterations affect B-cell receptor signaling in the most common type of lymphoma. Based on literature and our preliminary data, it is assumed that these alterations influence the dynamics of cortical actin and related B-cell receptor signaling.
- The proposed dissertation project focuses on basic research into the molecular mechanisms of multicombination vertical inhibition of the PI3K/AKT signaling pathway in B-cell lymphomas. The project builds on previous results from our research group, which showed that simultaneous inhibition of multiple regulatory levels of the PI3K/AKT pathway leads to more stable signaling inhibition than inhibiting individual members of the pathway.
- The proposed project aims to develop innovative chemo-free therapeutic strategies through organoid in vitro models that faithfully mimic the complex interactions between tumor cells and their microenvironment. These interactions cannot be explored in detail in conventional 2D cell models, which significantly limits the current understanding of the molecular mechanisms of lymphomagenesis and therapeutic resistance.
- Nanotechnology is a rapidly developing field with potential in cancer treatment. The aim of the project is to develop new approaches to assess the toxicity of nanomaterials and nano-bio interactions based on identifying their ability to induce various forms of regulated cell death (apoptosis, erythrocytosis, necrosis, ferroposis, pyroposis, etc.) with subsequent testing of the therapeutic applicability of the most promising nanomaterials.
We offer work in a friendly environment within a dynamic group with established international cooperation, operating in a modern scientific center with first-class research facilities. As part of your studies, you will have the opportunity to complete a 6-12 month internship abroad.
Fully funded positions are available with an expected start date in the 2026/2027 academic year.
If you are interested, please send your CV and a short summary of why you would be interested in working in our group to the following email address: ondrej.havranek@lf1.cuni.cz.