Group Name: Laboratory of Nanovesicle Engineering
Group Leader: Mgr. Andrea Gálisová, Ph.D.
Despite significant advancements in the development of therapeutic agents, many treatments fail to reach clinical application due to inefficient and non-specific delivery to target tissues. This limitation often results in reduced therapeutic efficacy and adverse side effects in healthy organs. Our research focuses on the development of advanced nanomaterials of biological or synthetic origin, designed to enable precise and efficient delivery of therapeutics.
We specialize in the engineering of extracellular vesicles (EVs) and synthetic nanocarriers as programmable delivery systems for therapeutically relevant cargo, including chemotherapeutics, immune modulators and proteins. Using cutting-edge synthetic biology approaches and nanotechnology, we develop strategies for nanocarrier surface functionalization and efficient cargo loading to achieve targeted delivery to tissues and treatment of diseases such cancer, neurological disorders or immune-related conditions.
The laboratory conducts preclinical research at the intersection of nanotechnology, cancer therapy, and molecular imaging. By integrating imaging probes compatible with magnetic resonance and optical imaging modalities, we monitor nanovesicle trafficking in living systems in order to evaluate and customize delivery efficiency. Our overall goal is to create safer, more effective and targeted therapeutics.
Group profile at the BIOCEV website TBD