Smetana Lab
Publications (dedicated to NPU=N or Biocev=B, international collaboration=I, collaboration with hospital=H, from group in Inst.131/from Detached group)
Mandys V, Popov A, Gürlich R, Havránek J, Pfeiferová L, Kolář M, Vránová J, Smetana K Jr, Lacina L, Szabo P. Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2023 Feb 10;24(4):3617. doi: 10.3390/ijms24043617. [PubMed] (131, H)
Smetana K Jr, Masařík M. Advances in Cancer Metabolism and Tumour Microenvironment. Int J Mol Sci. 2022 Apr 7;23(8):4071. doi: 10.3390/ijms23084071. (IF 6.208) [PubMed]
Rašková M, Lacina L, Kejík Z, Venhauerová A, Skaličková M, Kolář M, Jakubek M, Rosel D, Smetana K Jr, Brábek J. The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities. Cells. 2022 Nov 21;11(22):3698. doi: 10.3390/cells11223698. [PubMed] (131, H)
Gál P, Brábek J, Holub M, Jakubek M, Šedo A, Lacina L, Strnadová K, Dubový P, Hornychová H, Ryška A, Smetana K Jr. Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation. Histochem Cell Biol. 2022 Nov;158(5):415-434. doi: 10.1007/s00418-022-02140-x. [PubMed] (131, I, H)
Vokurka M, Lacina L, Brábek J, Kolář M, Ng YZ, Smetana K Jr. Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production. Int J Mol Sci. 2022 Jan 16;23(2):964. doi: 10.3390/ijms23020964.[PubMed] (131, I, H)
Strnadová K, Pfeiferová L, Přikryl P, Dvořánková B, Vlčák E, Frýdlová J, Vokurka M, Novotný J, Šáchová J, Hradilová M, Brábek J, Šmigová J, Rösel D, Smetana K Jr, Kolář M, Lacina L. Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts. Histochem Cell Biol. 2022 Feb;157(2):153-172. doi: 10.1007/s00418-021-02052-2. [PubMed] (131, H)
Melegová N, Čoma M, Urban L, Kaňuchová M, Szabo P, Smetana K Jr, Mučaji P, Gál P. Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma. Neoplasma. 2022 Jan;69(1):224-232. doi: 10.4149/neo_2021_210622N826. [PubMed] (131, I, H)
Vasilenko T, Kováč I, Slezák M, Ďurkáč J, Peržel'ová V, Čoma M, Kaňuchová M, Urban L, Szabo P, Dvořánková B, Vrzgula A, Zajíček R, Smetana K Jr, Gál P. Agrimonia eupatoria L. Aqueous Extract Improves Skin Wound Healing: An In Vitro Study in Fibroblasts and Keratinocytes and In Vivo Study in Rats. In Vivo. 2022 May-Jun;36(3):1236-1244. doi: 10.21873/invivo.12822. [PubMed] (IF 2.406) (131,I, H)
Brábek J, Jakubek M, Vellieux F, Novotný J, Kolář M, Lacina L, Szabo P, Strnadová K, Rösel D, Dvořánková B, Smetana K Jr. Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19. Int J Mol Sci. 2020 Oct 26;21(21):7937. doi: 10.3390/ijms21217937. (IF 4.183) [PubMed]
Abramenko N, Vellieux F, Tesařová P, Kejík Z, Kaplánek R, Lacina L, Dvořánková B, Rösel D, Brábek J, Tesař A, Jakubek M, Smetana K Jr. Estrogen Receptor Modulators in Viral Infections Such as SARS-CoV-2: Therapeutic Consequences. Int J Mol Sci. 2021 Jun 18;22(12):6551. doi: 10.3390/ijms22126551. (IF 5.923) [Pubmed] (H, 131)
Melegová N, Čoma M, Urban L, Kaňuchová M, Szabo P, Smetana K Jr, Mučaji P, Gál P. Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma. Neoplasma. 2022 Jan;69(1):224-232. doi: 10.4149/neo_2021_210622N826.[PubMed] (H, I, 131)
Novák Š, Kolář M, Szabó A, Vernerová Z, Lacina L, Strnad H, Šáchová J, Hradilová M, Havránek J, Španko M, Čoma M, Urban L, Kaňuchová M, Melegová N, Gürlich R, Dvořák J, Smetana K Jr, Gál P, Szabo P. Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts. Cancer Genomics Proteomics. 2021 May-Jun;18(3):221-243. doi: 10.21873/cgp.20254.[PubMed] (H, I, 131)
Smetana K Jr, Lacina L, Kodet O. Targeted Therapies for Melanoma. Cancers (Basel). 2020;12(9):E2494. Published 2020 Sep 3. doi:10.3390/cancers12092494. (IF 6.162) [Pubmed] (131, H)
Kodet O, Kucera J, Strnadova K, Dvorankova B, Stork J, Lacina L, Smetana K Jr. Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review). Int J Oncol. 2020;57(3):619-630. doi:10.3892/ijo.2020.5090. (IF 3.899) [Pubmed] (B, N, H, 131)
Smetana K Jr, Brábek J. Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications. In Vivo. 2020;34(3 Suppl):1589-1592. doi:10.21873/invivo.11947. (IF 1.541) [Pubmed] (131)Smetana K Jr, Rosel D, Brabek J.Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality. In Vivo. 2020;34(5):3027-3028. doi:10.21873/invivo.12135. (IF 1.541) [Pubmed] (131)
Strnadová K, Španko M, Dvořánková B, Lacina L, Kodet O, Shbat A, Klepáček I, Smetana K Jr. Melanoma xenotransplant on the chicken chorioallantoic membrane: a complex biological model for the study of cancer cell behaviour [published online ahead of print, 2020 Mar 30]. Histochem Cell Biol. 2020;10.1007/s00418-020-01872-y. doi:10.1007/s00418-020-01872-y. (IF 2.640) [PubMed] (B, N, 131)
Kodet O, Kucera J, Strnadova K, Dvorankova B, Stork J, Lacina L, Smetana K Jr. Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review). Int J Oncol. 2020;57(3):619-630. doi:10.3892/ijo.2020.5090. (IF 3.899) [Pubmed] (N, 131)
Strnadova K, Sandera V, Dvorankova B, Kodet O, Duskova M, Smetana K, Lacina L. Skin aging: the dermal perspective. Clin Dermatol. 2019 Jul - Aug;37(4):326-335. doi: 10.1016/j.clindermatol.2019.04.005.(IF 2.067) [PubMed]
Susanikova I, Puchľova M, Lachova V, Svajdlenka E, Mucaji P, Smetana K, Gal P. Genistein and Selected Phytoestrogen-Containing Extracts Differently Modulate Antioxidant Properties and Cell Differentiation: an in Vitro Study in NIH-3T3, HaCaT and MCF-7 Cells. Folia Biologica (Praha) 65,24-35 (2019) (IF 1.073) (B, N, I, 131)
Raudenska M, Balvan J, Fojtu M, Gumulec J, Masarik M. Unexpected therapeutic effects of cisplatin. Metallomics. 2019 Jul 17;11(7):1182-1199. doi: 10.1039/c9mt00049f.(IF 3.571) [PubMed] (131)
Vsiansky V, Svobodova M, Gumulec J, Cernei N, Sterbova D, Zitka O, Kostrica R, Smilek P, Plzak J, Betka J, Kalfert D, Masarik M, Raudenska M. Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers. Cells. 2019; 8(5):428. (IF 4.829) [Web] (H, 131)
Münster L, Fojtů M, Capáková Z, Vaculovič T, Tvrdoňová M, Kuřitka I, Masařík M, Vícha J. Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs. Biomacromolecules. 2019 Apr 8;20(4):1623-1634. doi: 10.1021/acs.biomac.8b01807. (IF 5.738) [PubMed] (131)
Plzák J, Bouček J, Bandúrová V, Kolář M, Hradilová M, Szabo P, Lacina L, Chovanec M, Smetana K Jr. The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy. Cancers (Basel). 2019 Mar 28;11(4). pii: E440. doi: 10.3390/cancers11040440. (IF 5.326) [PubMed] (B, N, 131)
Lacina L, Čoma M, Dvořánková B, Kodet O, Melegová N, Gál P, Smetana K Jr. Evolution of Cancer Progression in the Context of Darwinism. Anticancer Res. 2019 Jan;39(1):1-16. doi: 10.21873/anticanres.13074. (IF 1.865) [PubMed] (B, N, I, H, 131)
Peltanova B, Raudenska M, Masarik M. Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Mol Cancer. 2019 Mar 30;18(1):63. doi: 10.1186/s12943-019-0983-5. (IF 7.78) [PubMed] (131)
Lacina L, Brábek J, Král V, Kodet O, Smetana K Jr. Interleukin-6: a molecule with complex biological impact in cancer. Histol Histopathol. 2019 Feb;34(2):125-136. doi: 10.14670/HH-18-033. (IF 2.015) [PubMed] (B, N, 131)
Dvořánková B, Lacina L, Smetana K Jr. Isolation of Normal Fibroblasts and Their Cancer-Associated Counterparts (CAFs) for Biomedical Research. Methods Mol Biol. 2019;1879:393-406. doi: 10.1007/7651_2018_137. (IF N/A) [PubMed] (B, N, 131)
Zivicova V, Gal P, Mifkova A, Novak S, Kaltner H, Kolar M, Strnad H, Sachova J, Hradilova M, Chovanec M, Gabius HJ, Smetana K JR., Fik Z. Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma. Anticancer Res. 2018 Mar;38(3):1279-1290. (IF 1.865) [PDF] (B, N, I, H, 131)
Lacina L, Kodet O, Dvořánková B, Szabo P, Smetana K Jr. Ecology of melanoma cell. Histol Histopathol. 2018 Mar;33(3):247-254. doi: 10.14670/HH-11-926. Epub 2017 Aug 29. Review. PubMed PMID: 28849859. (IF 2.015) [PubMed] (N)
Jobe NP, Živicová V, Mifková A, Rösel D, Dvořánková B, Kodet O, Strnad H, Kolář M, Šedo A, Smetana K Jr., Strnadová K, Brábek J, Lacina L. Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes. Histochem Cell Biol. 2018 Feb 12. doi: 10.1007/s00418-018-1650-4. (IF 2.164) [PubMed] (B, N, I, 131)
Kodet O, Dvořánková B, Bendlová B, Sýkorová V, Krajsová I, Štork J, Kučera J, Szabo P, Strnad H, Kolář M, Vlček Č, Smetana K Jr, Lacina L. Microenvironment‑driven resistance to B‑Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Int J Mol Med. 2018 May;41(5):2687-2703. doi: 10.3892/ijmm.2018.3448. (IF 2.784) [PDF] (B, N, H, 131)
Smetana K, Dvořánková B, Lacina L, Szabo P, Brož P, Šedo A. Cancer: The Price for Longevity. Aging: Exploring a Complex Phenomenon. 1 vyd. Boca Raton: Taylor & Francis, 2018, s. 237-245. ISBN 978-1-138-19697-1. Book chapter. (IF N/A)
How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair. Gál P, Varinská L, Fáber L, Novák Š, Szabo P, Mitrengová P, Mirossay A, Mučaji P, Smetana K. Molecules. 2017 Oct 26;22(11). pii: E1818. doi: 10.3390/molecules22111818. Review. (IF 2.861) [PDF] (B, N, I, H)
Analysis of dermal fibroblasts isolated from neonatal and child cleft lip and adult skin: Developmental implications on reconstructive surgery. Zivicova V, Lacina L, Mateu R, Smetana K Jr., Kavkova R, Krejci Drobna E, Grim M, Kvasilova A, Borsky J, Strnad H, Hradilova M, Sachova J, Kolar M and Dvorankova B. Int. J. Mol. Med. 40: IJMM-2439-187533-Dvorankova OA, Aug 2017. (IF 2.341) [PDF] (B, N)
Genome-wide Expression Profiling (with Focus on the Galectin Network) in Tumor, Transition Zone and Normal Tissue of Head and Neck Cancer: Marked Differences Between Individual Patients and the Site of Specimen Origin. Zivicova V, Broz P, Fik Z, Mifkova A, Plzak J, Cada Z, Kaltner H, Kucerova JF, Gabius HJ, Smetana K Jr. Anticancer Res. 2017 May;37(5):2275-2288. (IF 1.895) [PDF] (B, N, I)
Phenotypic characterization of oral mucosa: what is normal? Valach J, Foltán R, Vlk M, Szabo P, Smetana K Jr. J Oral Pathol Med. 2017 Jan 31.doi: 10.1111/jop.12556. (IF 1.859) [PDF]
Intercellular crosstalk in human malignant melanoma. Dvořánková B, Szabo P, Kodet O, Strnad H, Kolář M, Lacina L, Krejčí E, Naňka O, Šedo A, Smetana K Jr. Protoplasma. 2017, roč- 254, č.3, s.1143-1150,8s. ISSN 0033-183X. DOI: 10.1007/s00709-016-1038-z. (IF. 2.343) [PDF] (B, N, D)
Fibroblasts as Drivers of Healing and Cancer Progression: From In vitro Experiments to Clinics. Eliška Krejčí, Barbora Dvořánková, Pavol Szabo, Ondřej Naňka, Hynek Strnad, Ondřej Kodet, Lukáš Lacina, Michal Kolář and Karel Smetana, jr. Molecular Mechanisms of Skin Aging and Age-Related Diseases. 2016 June 18. ISBN: 978-1-4987-0465-6 [PDF] (B, D)
Smorodinova N, Kaltner H, Jirsová K, Hrdličková-Cela E, André S, Kučera T, Smetana K Jr, Gabius HJ. Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note. Curr Eye Res. 2016 Jun;41(6):740-6. doi: 10.3109/02713683.2015.1061022.(IF 2.025)[PubMed](B, H, D)
Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness. Jobe NP, Rösel D, Dvořánková B, Kodet O, Lacina L, Mateu R, Smetana K, Brábek J. Histochem Cell Biol. 2016 Apr 21. (IF 2.780) [PDF] (B, N, 131)
ROSANA MATEU, VERONIKA ŽIVICOVÁ, ELIŠKA DROBNÁ KREJČÍ, MILOŠ GRIM, HYNEK STRNAD, ČESTMÍR VLČEK, MICHAL KOLÁŘ, LUKÁŠ LACINA, PETER GÁL, JIŘÍ BORSKÝ, KAREL SMETANA JR and BARBORA DVOŘÁKOVÁ. Functional differences between neonatal and adult fibroblasts and keratinocytes: Donor age affects epithelial-mesenchymal crosstalk in vitro. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. DOI: 10.3892/ijmm.2016.2706. (IF 2.348) [PDF] (B, N, I, H, 131)
Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing. Peržeľová V, Sabol F, Vasilenko T, Novotný M, Kováč I, Slezák M, Ďurkáč J, Hollý M, Pilátová M, Szabo P, Varinská L, Čriepoková Z, Kučera T, Kaltner H, André S, Gabius HJ, Mučaji P, Smetana K Jr, Gál P. Int J Mol Med. 2016 Jan;37(1):21-8. (IF 2.348) [PDF] (B, I, H, D)
KAREL SMETANA JR., LUKÁŠ LACINA, PAVOL SZABO, BARBORA DVOŘÁNKOVÁ, PROKOP BROŽ and ALEKSI ŠEDO. Ageing as an Important Risk Factor for Cancer. ANTICANCER RESEARCH 36: 5009-5018 (2016).DOI: 10.21873/anticanres.11069. (IF 1.895) [PDF] (N, I, H, 131)