1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University BIOCEV
tstopka 15.05.2016

Kostrouch Lab

Lab Members

Contact: zdenek.kostrouch@lf1.cuni.cz

Kostrouch Zdeněk, Kostrouchová Marta, Kostrouchová Markéta,

Kollárová Johana, Prouzová Hana, Yilma Petr, Zadinová Lucie, Kostrouchová Veronika.

Kostrouch David, Chughtai Ahmed Ali, Novotný Jan Philipp, Kaššák Filip, Al-Redouan Azzat.

Zima Vladimír, Šebková Kateřina, Čapková Tereza, Kouns Nathaniel.


Recent Publications

Chughtai AA, Kaššák F, Kostrouchová M, Novotný JP, Krause MW, Saudek V, Kostrouch Z, Kostrouchová M. Perilipin-related protein regulates lipid metabolism in C. elegans. PeerJ. 2015 Sep 1;3:e1213. doi: 10.7717/peerj.1213. eCollection 2015.

Zima V, Šebková K, Šimečková K, Dvořák T, Saudek V, Kostrouchová M. Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans. Folia Biol (Praha). 2015;61(5):168-77.


Publications related to our current mission

Chughtai AA, Kaššák F, Kostrouchová M, Novotný JP, Krause MW, Saudek V, Kostrouch Z, Kostrouchová M. Perilipin-related protein regulates lipid metabolism in C. elegans. PeerJ. 2015 Sep 1;3:e1213. doi: 10.7717/peerj.1213. eCollection 2015.

Kostrouch D, Kostrouchová M, Yilma P, Chughtai AA, Novotný JP, Novák P, Kostrouchová V, Kostrouchová M, Kostrouch Z. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. J Proteomics. 2014 Oct 14;110:93-106. doi: 10.1016/j.jprot.2014.07.023. Epub 2014 Aug 1.

Kostrouchova M, Kostrouch Z. Nuclear receptors in nematode development: Natural experiments made by a phylum. Biochim Biophys Acta. 2015 Feb;1849(2):224-37. doi: 10.1016/j.bbagrm.2014.06.016. Epub 2014 Jun 28.

Mikoláš P, Kollárová J, Sebková K, Saudek V, Yilma P, Kostrouchová M, Krause MW, Kostrouch Z, Kostrouchová M. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. PLoS One. 2013;8(3):e58462. doi: 10.1371/journal.pone.0058462. Epub 2013 Mar 6.

Kouns NA, Nakielna J, Behensky F, Krause MW, Kostrouch Z, Kostrouchova M. NHR-23 dependent collagen and hedgehog-related genes required for molting. Biochem Biophys Res Commun. 2011 Oct 7;413(4):515-20. doi: 10.1016/j.bbrc.2011.08.124. Epub 2011 Sep 2.

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Our indoor and outdoor labs may be quite different at first glance but they share many aspects.

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Lab scope and current directions

1. Evolution - Archetypal regulatory pathways

Regulation of gene expression from invertebrate model organisms (C. elegans, platyhelmintes, diploblasts) to human diseases (cancer).

2. Bioengineering - Artificial evolution for the betterment of life

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Artificial mangroves in Vestec and the Botanical garden Průhonice both provide plenty of species and biological inspiration.

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