Using a precisely defined genetic model of self-antigen driven B-cell receptor (BCR) signaling (one of key characteristics of lymphomas), the study provided evidence that BCR internalization is essential for activation of oncogenic BCR signal and that the process of BCR internalization could be therapeutically targeted. This study thus provides basic information about critical lymphoma biology and opens new therapeutic opportunities using already approved drugs.
Górniak P, Polak A, Rams A, Kupcova K, Głodkowska-Mrówka E, Pilch Z, Miączyńska M, Nowis D, Gołąb J, Davis RE, Havranek O, Juszczyński P. Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in diffuse large B cell lymphoma (DLBCL). Cell Death Dis. 2026 Feb 11;17(1):216. (IF 9.6, Q1) [PubMed]
