1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University BIOCEV
tstopka 16.06.2017

PHEO/PGL PROTEOME

THE FIRST ON-LINE DRAFT OF HUMAN PHEOCHROMOCYTOMA/PARAGANGLIOMA PROTEOME

Pheochromocytomas and paragangliomas (PHEO/PGL) are rare neuroendocrine tumors arising from chromaffin cells of adrenal medulla and from extra-adrenal sympathetic­ and parasympathetic ganaglia, respectively. Low incidence (0.8 per 100 000) classifies PHEO/PGL among rare diseases. The majority of PHEO/PGL are benign, yet show high morbidity and mortality due to excessive production of catecholamines, leading to hypertension, arrhythmia and stroke. Up to 25 percent are malignant. Therapy for patients with metastatic PHEO/PGL is limited with 5 year survival often less than 50 percent. 

Pilot analysis of human pheochormocytoma sample. (Nearly 4000 proteins identified) Human pheochromocytoma sample digested with trypsin and subjected to LC-MS/MS analysis (2 hour gradient RP-LC, Orbitrap Fusion MS/MS, search performed by ProteomeDiscoverer)

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