CML EXOSOME PROTEOME
Exosomes are small membrane vesicles released by cells as mediators of cell-to-cell communication. Tumor-derived exosomes have been shown to carry pro-survival signals and may mediate drug resistence. The“information cargo” carried by exosomes is an attractive candidate for a potential therapeutic intervention in cancer therapy. Our aim is a detailed analysis of exosome cargo released by leukemia cells, namely by cells of chronic myelogenous leukemia (CML).
CORE CML EXOSOME PROTEOME consit of 1500 consensus proteins identified in four independent isolates of CML exosomes released by K562 cells.